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Monday, May 14, 2012
  Clinical Accuracy Spoken Here  

MS: T-cells Attack Self

T cells contribute to the body's defenses. Regulatory T cells orchestrate the immune system. Helper T cells activate the body's defenses against foreign substances. A subset of T cells turn off various immune system cells when their job is done.

Killer T cells conversely directly attack diseased or damaged body cells by binding to them and bombarding them with lethal cytokines.

In autoimmune diseases such as MS, the immune system seems to wrongly identify self as non-self and attacks the myelin it no longer recognizes.

[Reference: MS, Module A, Pathophysiology]
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  Excellence in Case Mgmt  

MS QOL Issues

A frequent concern for patients with MS is their ability to enjoy an active sex life. This may be very difficult to discuss with a healthcare provider. The patient may have the perception that the sexual changes are reflective of relationship issues. Although there is an impact on relationships the sexual dysfunction may be directly related to the neurological changes or the medications.

Case Managers need to provide the opportunity for issues about physical changes to be discussed openly so the appropriate treatments or guidance can be achieved.

[Reference: MS, Module D, CM Role]
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  Improving Patient Care...  

Oral Med for MS

Gilenya® (fingolimod) is the first oral MS medication and as such, it may significantly heighten MS patients' success in adhering to therapy.

The second distinction is its mode of action. Gilenya binds to a docking site (sphingosine-1-phosphate receptor) on immune cells, including T cells and B cells that have been implicated in causing nervous system damage in MS. It appears to force some immune cells to remain in lymph nodes, and inhibits them from migrating into the brain and spinal cord.

It is approved for the treatment of adults with relapsing forms of MS.

[Reference: MS Course Home Page]
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Tom RasmussenTom Rasmussen
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