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Monday, August 13, 2012
  Clinical Accuracy Spoken Here  

CRC: Genetic Contribution

About 75% of patients with colorectal cancer have no apparent evidence of having inherited the disorder.

The remaining 25% of patients have a family history of colorectal cancer that suggests a genetic contribution.

Genetic mutations have been identified as the cause of inherited cancer risk in some colon cancer-prone families accounting for only 5% to 6% of crc cases overall. It is likely that other undiscovered major genes and background genetic factors contribute to the development of crc, in conjunction with nongenetic risk factors.

[Reference: CRC, Module A, Pathophysiology]

  Excellence in Case Mgmt  

CRC: Areas of Research

Researchers are studying:

  • Chemotherapy: Researchers are testing new anticancer drugs and drug combinations. They also are studying combinations of drugs and radiation therapy before and after surgery.
  • Biological therapy: New biological approaches are also under study. Biological therapy uses the body's natural ability (immune system) to fight cancer
  • Combination therapies

[Reference: CRC, Module C, Treatment]

  Improving Patient Care...  

CRC: Practice Guidelines

The Agency for Healthcare Research and Quality provides a resource of practice guidelines via the National Guidelines Clearinghouse.

Most of the guidelines are not from U.S. government resources but from professional organizations and some are international.

The guidelines primarily focus on prevention aspects of colorectal cancer. For specifics, see CRC Course, Module B, page 13.

[Reference: CRC, Module B, Symptoms and Management]


Tom RasmussenTom Rasmussen
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