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Monday, September 10, 2012
  Clinical Accuracy Spoken Here  

CRC: Carcinogenesis

Colorectal cancer (CRC) tumors present with a broad spectrum of neoplasms, ranging from benign growths to invasive cancer, and are predominantly epithelial-derived tumors (i.e., adenomas or adenocarcinomas).

Pathologists have classified the lesions into 3 groups: non-neoplastic polyps, neoplastic polyps (adenomatous polyps, adenomas), and cancers. Experts believe that most colorectal cancers develop from adenomas.

The exact causes of colorectal cancer are not known.

[Reference: Colorectal Cancer, Module A, Pathophysiology]
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  Excellence in Case Mgmt  

CRC Staging Determines Treatment

Staging of cancer is related to all aspects of treatment. The National Comprehensive Cancer Network (NCCN) bases its recommended treatment standards on the stage of the cancer. Treatment guidelines primarily focus on prevention aspects of colorectal cancer.

As rectal cancer progresses from Stage 0 to IV, the cancer cells grow through the layers of the rectum wall and spread to lymph nodes and other organs.

[Reference: Colorectal Cancer, Module B, Symptoms and Management]
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  Improving Patient Care...  

CRC: What are the different types of clinical trials?

Treatment trials test experimental treatments, new combinations of drugs, or new approaches to surgery or radiation therapy.

Prevention trials look for better ways to prevent disease or to prevent a disease from returning.

Diagnostic trials are conducted to find better tests or procedures for diagnosing a particular disease or condition.

Screening trials test the best way to detect certain diseases or conditions.

Quality of Life trials explore ways to improve comfort and quality of life for individuals with a chronic illness.

[Reference: Colorectal Cancer, Module C, Treatment]
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Tom RasmussenTom Rasmussen
Publisher
Athena Forum
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Cathy WrightCathy Wright, BSN, RN
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