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Monday, November 26, 2012
  Clinical Accuracy Spoken Here  

Obesity: Genetic Influences

Progress in identifying the multiple genes associated with the most common form of obesity has been slow but is accelerating. As of October 2005 the Human Obesity Gene Map indicates:

  • Single mutations in 11 genes were strongly implicated in 176 cases of obesity worldwide
  • 50 chromosomal locations relevant to obesity have been mapped, with potential causal genes identified in most of those regions.

While knowledge about the genetics of obesity is growing, many questions still remain.

[Reference: Obesity Management, Module A, Prevalence & Pathophysiology]

  Excellence in Case Mgmt  

Obesity Management:
Physical Activity Required

Individuals considered overweight or obese are encouraged to work up to 60 to 90 minutes of moderate intensity exercise a day to achieve and sustain weight loss.

As new technologies such as mobile phone devices become more sophisticated, the case manager may want to include available applications in the care planning process including:

  • Applications that track calorie intake in sample restaurant menu items
  • Pedometer applications

[Reference: Obesity, Module D, CM Role]

  Improving Patient Care...  

Obesity: The Function of Fat

Adipose tissue is a highly active metabolic and endocrine organ. The two types of human adipose tissue are:

  • Brown (BAT) - specialized in energy expenditure; can counteract obesity
  • White (WAT) - the primary site of triglyceride (fat) storage

BAT cells are metabolically active, dissipating chemical energy in the form of heat and acting as a physiological defense against cold and obesity.

The analysis of the origin and function of adipose tissue indicates there are opportunities for the development of new therapeutics for obesity and type 2 diabetes.

[Reference: Obesity Management, Module A, Prevalence & Pathophysiology]


Tom RasmussenTom Rasmussen
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