About RA: What is Known?
The clinical manifestations of RA result from a complex interaction in the synovial tissues.
Genetic factors play an important role and likely account for 50% to 60% of the risk of developing RA.
Cigarette smoking by far has the strongest RA risk association among environmental factors.
RA begins insidiously over weeks to months and has five pathophysiologic stages.
It is prudent not to ignore symptoms such as polyarticular inflammation, morning stiffness, and constitutional signs like weight loss, fever, and/or fatigue.
Cardiovascular and respiratory disorders have the greatest impact, accounting for 58% of RA deaths.