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Sepsis: Long-term Vulnerability
Some of the long-lasting effects of sepsis are obvious, such as missing limbs and organ dysfunction. Some after effects of sepsis are less obvious, such as depression, memory loss and the inability to do simple arithmetic.
There is some evidence that an episode of severe sepsis disrupts peoples' immune system, making them more vulnerable to future infections. Studies have shown that people who have experienced sepsis have an increased risk of dying, even several years after the episode.
Sepsis patient education should balance patient information needs with the need for emotional support.
Athena Forum Sepsis, Module E, Case Manager's Role
Sepsis: The 1 Hour Paradigm
Prompt infusion of antimicrobial agents is a priority and may require additional vascular access ports.
When septic shock is present, each hour of delay in achieving administration of effective antibiotics is associated with a measurable increase in mortality. According to the Surviving Sepsis Guidelines; antimicrobials should be administered within three hours of arrival to the Emergency Department (ED).
In the largest study of antimicrobials in septic shock, patients who received "effective" antibiotics within one hour of the development of hypotension had a survival of 79.9%. This dropped by 7.6% with every hour in delay of administration.
Athena Forum Sepsis, Module D, Prevention and Treatment